Kenneth Irvine

The Irvine Lab investigates intercellular signaling networks and the influence of these signaling networks on cell fate, organ growth, and morphogenesis, using both Drosophila and mammalian models. We study both the molecular mechanisms of signal transduction, and the roles of signaling pathways in different developmental and physiological contexts. A current focus is on how cells perceive their mechanical environment, and how tissue mechanics influences organ growth and morphogenesis. We also investigate relationships between spatial patterning and growth in developing and regenerating organs and how patterning inputs are integrated with other factors that influence organ growth, including tissue mechanics.