Arek Kulczyk

Arek Kulczyk is a biophysicist who combines experimental and computational approaches to study the structure and dynamics of large macromolecular assemblies with medical relevance. The Kulczyk Lab integrates structural methods, including cryo-EM/ET, NMR, X-ray crystallography, and molecular dynamics simulations using Anton supercomputers, with the development of novel time-resolved CLEM and single-molecule methods. These tools are used to investigate, for example, the molecular basis of basement membrane assembly and the coordination of DNA synthesis. By leveraging this integrative toolkit, the group uncovers mechanistic insights that enable the development of novel therapeutics through AI-driven structure-based drug design and protein engineering.

Dr. Kulczyk earned his Ph.D. from the MRC Laboratory of Molecular Biology at the University of Cambridge and completed his postdoctoral training at Harvard University. Prior to joining Rutgers, he held a junior faculty appointment at Harvard Medical School, where he established an independent research program.